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LABS
Use Cases

Real-Time Drug Efficacy Visibility for Payers

Leverage blockchain to aggregate real-world therapy performance data across your member base, enabling data-driven coverage decisions and stronger pharmaceutical negotiations.
Chainscore © 2026
problem-statement
HEALTHCARE PAYERS

The Challenge: Flying Blind on Drug Performance

Payers and PBMs manage billions in drug spend without real-time visibility into real-world patient outcomes, leading to inefficient formularies and rising costs.

For a Chief Financial Officer at a major health plan, the current process for evaluating drug efficacy is a costly black box. Decisions on formulary placement and value-based contracts rely on delayed, aggregated claims data and sporadic clinical studies that can take years to complete. This means you're paying premium prices for therapies without knowing if they are delivering better outcomes for your specific member population in real-world use. The financial risk is immense, as ineffective drug spending directly erodes margins and drives up premiums.

The blockchain fix creates an immutable, permissioned ledger for Real-World Evidence (RWE). With patient consent, anonymized treatment outcomes and adherence data from EHRs, pharmacies, and wearables can be securely aggregated. Smart contracts automate the process, stripping identifying details and feeding structured efficacy data to payers. This transforms RWE collection from a manual, multi-year research project into a continuous, automated data stream, providing a near real-time view of a drug's performance across diverse demographics.

The ROI is quantifiable across three key areas: cost avoidance from deprioritizing underperforming drugs, negotiation leverage with pharma companies using validated outcome data, and compliance with value-based contract terms. For instance, a payer could automatically trigger rebates from a manufacturer if a drug fails to meet a pre-defined efficacy threshold in their population, enforced by a smart contract. This shifts the financial risk and aligns incentives, turning drug spend from a fixed cost into a variable, performance-based investment.

key-benefits
REAL-TIME DRUG EFFICACY FOR PAYERS

Key Business Benefits: From Data Blindness to Strategic Insight

Move beyond delayed claims data to a real-world evidence ecosystem. Blockchain enables payers to access immutable, patient-consented treatment outcomes, transforming formulary decisions and contract negotiations.

03

Fraud & Waste Reduction

Gain an immutable audit trail for every prescription and associated outcome, dramatically reducing areas of loss.

  • Detect prescription fraud by tracking drug provenance and patient consent on an unchangeable ledger.
  • Identify clinical waste by highlighting therapies with high rates of discontinuation or switch due to ineffectiveness.
  • Quantifiable Impact: The NIH estimates billions are lost annually to healthcare fraud. A transparent ledger can help payers recover a significant portion by providing irrefutable proof of anomalous patterns.
04

Accelerated Prior Authorization

Streamline the most burdensome administrative process by using a patient-owned health record. With patient consent, providers can instantly share verified diagnosis and treatment history, enabling near-instant authorization decisions.

  • Reduce decision time from days to minutes.
  • Lower administrative costs for both payers and providers.
  • Improve member satisfaction by removing care delays. This turns a cost center into a competitive advantage in member retention.
05

Competitive Market Intelligence

Build a proprietary data asset on real-world drug performance. Anonymized, aggregated insights from your member population become a strategic tool for negotiating with pharmaceutical manufacturers.

  • Leverage data in PBM and manufacturer negotiations to secure better pricing based on your population's specific outcomes.
  • Identify unmet needs and partner with biotech firms on targeted solutions.
  • This transforms data from a compliance burden into a core competitive differentiator.
COST-BENEFIT ANALYSIS

ROI Breakdown: Quantifying the Value

Comparing the financial and operational impact of traditional claims review versus a blockchain-enabled real-time efficacy network for a mid-sized payer.

Key MetricLegacy Claims ReviewBlockchain Real-Time NetworkNet Benefit

Average Time to Detect Inefficacy

90-120 days

< 24 hours

~99% faster

Fraud & Waste Reduction Potential

2-5% of Rx spend

8-12% of Rx spend

+6-7% savings

Manual Adjudication Labor (FTE/year)

15

3

12 FTE reduction

Prior Authorization Auto-Approval Rate

15%

65%

+50% automation

Audit & Compliance Preparation Cost

$250k - $500k

$50k - $100k

80% cost reduction

Patient Outcomes Improvement (Adherence)

Baseline

+15-20%

Reduced hospitalizations

Implementation & Annual Operating Cost

N/A (Baseline)

$1.2M - $2M

Payback in 18-24 months

real-world-examples
HEALTHCARE PAYERS

Real-World Applications & Pioneers

Leading health insurers and PBMs are deploying blockchain to transform drug efficacy data from a liability into a strategic asset, unlocking new value streams and reducing costs.

01

Automated Outcomes-Based Contracting

Replaces manual, dispute-prone rebate processes with smart contracts that execute automatically based on verified patient outcomes. This eliminates reconciliation costs and ensures payers only pay for drugs that work as promised in real populations.

  • Real Example: Aetna (CVS Health) has piloted blockchain to manage value-based agreements for specialty drugs, reducing administrative overhead by an estimated 30-40%.
  • ROI Driver: Direct link between payment and proven efficacy protects margins and improves formulary decision-making.
30-40%
Admin Cost Reduction
02

Fraud & Waste Detection in Real-Time

Creates an immutable, shared ledger of prescription fills, patient diagnoses, and treatment outcomes. This single source of truth allows AI models to detect patterns indicative of fraud, off-label promotion, or ineffective prescribing in near real-time.

  • The Pain Point: The US healthcare system loses an estimated $100B+ annually to fraud and waste.
  • The Blockchain Fix: Early anomaly detection prevents payouts for non-compliant or ineffective treatments, directly protecting the bottom line.
03

Streamlined Prior Authorization

Enables secure, patient-controlled sharing of verifiable health credentials and historical treatment data. This gives payers the evidence needed to approve or deny high-cost therapy requests instantly, without manual record chasing.

  • Business Benefit: Reduces approval cycles from days to minutes, improving member satisfaction while ensuring compliance with clinical guidelines.
  • Real-World Pioneer: Anthem (now Elevance Health) has explored blockchain-based platforms to give members control over their health data, streamlining access for providers and payers alike.
05

Supply Chain Provenance & Recall Management

Tracks pharmaceuticals from manufacturer to pharmacy with granular serialization. For payers, this mitigates the cost and liability of counterfeit drugs entering the network and enables instantaneous, targeted recalls.

  • The Pain Point: Counterfeit drugs cost the global industry over $200B annually and pose severe patient safety risks.
  • The Blockchain Fix: Provenance tracking ensures plan dollars are spent on authentic products. In a recall, affected batches are identified in seconds versus weeks, minimizing member risk and claims expense.
06

Compliance & Audit Trail Automation

Provides an immutable, timestamped record of all data access, contract executions, and coverage decisions. This automated audit trail dramatically reduces the cost and complexity of regulatory compliance (e.g., for CMS, HIPAA, SOX).

  • Cost Savings: Reduces manual audit preparation labor by an estimated 50-70%.
  • Business Enabler: Creates a defensible position for coverage decisions, demonstrating rigorous, data-driven processes to regulators and auditors.
REAL-TIME DRUG EFFICACY VISIBILITY

Navigating Adoption Challenges

Implementing blockchain for real-world evidence in pharma-payer contracts presents unique hurdles. This section addresses the critical business, technical, and compliance questions that arise during the evaluation and adoption process.

The ROI is driven by automated value-based contracting and reduced administrative overhead. Traditional outcomes verification is manual, slow, and costly, involving audits and data reconciliation. A blockchain-based system automates data collection from trusted sources (EHRs, wearables) and executes smart contracts when predefined efficacy milestones are met. This reduces the cost of contract administration by 40-60% and accelerates rebate/payment cycles from months to days. The primary value is shifting from paying for volume to paying for verifiable patient outcomes, directly aligning cost with therapeutic success.

pilot-program
BLOCKCHAIN IN HEALTHCARE

The 90-Day Pilot: Start Small, Prove Value

Demonstrate tangible ROI on a focused use case before scaling. This pilot targets the multi-billion-dollar challenge of post-market drug efficacy and adverse event reporting.

01

Eliminate Reconciliation & Audit Costs

Today, payers and providers spend millions reconciling disparate data from EHRs, labs, and pharmacies to assess a drug's real-world performance. A permissioned blockchain creates a single, immutable source of truth for treatment outcomes and patient-reported data. This eliminates manual reconciliation, reduces audit preparation time by up to 70%, and provides a verifiable audit trail for regulatory compliance (FDA, EMA).

70%
Faster Audit Prep
02

Accelerate Value-Based Contract Payouts

Outcomes-based contracts are stalled by manual, disputable data collection. Smart contracts can automate payouts based on verifiable efficacy data recorded on-chain. For example, a contract for a diabetes drug could automatically trigger rebates to a payer if aggregate patient A1C levels don't improve by a predefined threshold within 6 months. This reduces administrative overhead and builds trust between manufacturers and payers.

90 Days
Faster Payout Cycles
04

Pilot Scope: One Drug, One Payer Network

Minimize risk and complexity. A successful pilot focuses on a single high-cost specialty drug (e.g., a novel oncology therapy) within one payer's network. Onboard 5-10 provider sites and a few hundred consenting patients. Track key efficacy metrics (e.g., tumor response, progression-free survival) and patient-reported outcomes. The goal is not a full rollout, but to prove data integrity, process efficiency, and a clear path to ROI within one quarter.

< 90 Days
To Initial ROI Proof
05

Quantifiable ROI for the CFO

The pilot's business case is built on hard savings and risk mitigation:

  • Reduced administrative cost: Cut manual data aggregation and dispute resolution by an estimated 30-40%.
  • Faster contract cycles: Accelerate rebate and value-based payments, improving cash flow.
  • Compliance risk reduction: Mitigate fines and litigation with an immutable audit trail.
  • Strategic data asset: Create a new, high-integrity data product for market analysis and research.
30-40%
Admin Cost Reduction
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